Isopropyl myristate resultz 50% topical solution class of drugs. The substance identity section is calculated from substance identification information from all echa databases. Chemical product and company identification product name. Isopropyl myristate is defined as a synthetic oil that is popularly used in both the cosmetics industry as well as the pharmaceutical industry. Isopropyl myristate 225 version 2 revision date 07112008 print date 07112008 page 4 8 requirements for storage areas and containers. Ester of isopropyl alcohol and myristic acid vegetablederived. Isopropyl myristate safety data sheet according to federal register vol. In addition, it is also used to help solubilise actives such as sunscreens, vitamins and perfumes into a base. Containers which are opened must be carefully resealed and kept upright to. The substance identifiers displayed in the infocard are the best available substance name, ec number, cas number andor the molecular and structural formulas. Isopropyl myristatecyclomethicone d5, is a topical formulation containing 5050 ww isopropyl myristatedecamethylcyclopentasiloxane. It is most often used an an additive in aftershaves, shampoos, bath oils, antiperspirants. Pdf enzymatic synthesis of isopropyl myristate using. Safety data sheet isopropyl myristate date prepared.
Toxicity profile for isopropyl myristate 2005 bibra. Lastly, isopropyl myristate is also believed to have strong skin penetrating properties. Green synthesis of isopropyl myristate in novel single. Steritest ez system sterility testing of products to be. Amended safety assessment of alkyl esters as used in cosmetics. Isopropyl myristate is a light, colorless, oily liquid. Find patient medical information for isopropyl myristate bulk on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings.
Isopropyl myristate msds material safety data sheet isopropyl myristate 1. Pdf isopropyl myristate production process optimization. Safety data sheet a university in missouri, college in. Its also perfect as a perfume diluent in place of other oils or alcohol. Pediculicide widespread and common in children between the ages of 3 and 12. Isopropyl myristate ipm has produced slight irritation of human skin, mild irritation of the rabbit eye and moderate irritation of rabbit skin. Isopropyl myristate cas 110270 817066 emd millipore. Its used in cosmetic and topical medicinal preparations. The myristic acid and isopropanol when used at a concentration of 100 mm each in nheptane resulted in formation of isopropyl myristate 66. It is labeled for the control of ticks on dogs and cats.
Isopropyl myristate msds material safety data sheet or sds, coa and coq, dossiers. Eye contact rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Isopropyl myristate tetradecanoic acid, 1 methylethyl. Parchem is open and ready to supply materials 18002823982 read more. Committee to evaluate drugs ced isopropyl myristate. Emulsifiers humectants binders emollients inci names. Effectiveness of isopropyl myristatecyclomethicone d5. Isopropyl myristate 98% isopropyl tetradecanoate sigmaaldrich. Spectrum chemical nf products are manufactured, packaged and stored under current good manufacturing practices cgmp per 21cfr part 211 in fda registered and inspected facilities. Isopropyl myristate cas 110270 822102 emd millipore. Isopropyl linoleate is the ester of isopropyl alcohol and linoleic acid. Ipm 100, ipmex, ipmr, ipm, isopropyl tetradecanoate, myristic acid isopropyl ester linear formula. Isopropyl myristate, nf is an emollient ester of low viscosity used to reduce the greasiness of emulsions. Isopropyl myristate revision date 24jan2018 component casno weight % isopropyl myristate 110270 95 4.
Cetyl esters include cetyl palmitate, cetyl stearate, myristyl myristate. Isopropyl myristate, with the chemical formula ch 3 ch 2 12 cooch ch 3 2 4, is an ester of myristic acid, an essential fatty acid derived from palm kernel oil and isopropyl alcohol. According to a more recent reference cornell university. Ipm 100, ipmex, ipmr, ipm, isopropyl tetradecanoate, myristic acid isopropyl ester cas number 110270. Sep 03, 2012 isopropyl myristate cyclomethicone d5, is a topical formulation containing 5050 ww isopropyl myristate decamethylcyclopentasiloxane. Material safety data sheet section 1 isopropyl myristate 1 chemical product and company identification msds name. Other local effects have included nasal and lung irritation during inhalation of aerosols in monkeys and rats, acne development after application to rabbit skin, and increased permeability of human. The clp regulation makes sure that the hazards presented by chemicals are clearly communicated to. The hazard classification and labelling section shows the hazards of a substance based on the standardised system of statements and pictograms established under the clp classification labelling and packaging regulation. Often used as a diluent in the making of perfumes or added to creams and lotions etc. Find msds or sds, a coa, data sheets and more information.
Analysis of impurities of isopropyl myristate by gas. In cosmetic manufacturing this ingredient is used to give the finished product a slicker, smoother feel rather than an oily one inci name. Isopropyl myristate, food and flavor ingredient, flavis no. Isopropyl myristate can be used to dilute aroma chemicals. The new york state department of health doh has evaluated the risk of the proposed use of isopropyl. It is also used as a pesticide against head lice which works. This allnatural ester is used to empart a dry yet moisturising feel to skin creams.
Apr 19, 2017 isopropyl myristate is defined as a synthetic oil that is popularly used in both the cosmetics industry as well as the pharmaceutical industry. Safety data sheet northwest missouri state university. Long chain fatty acid esters, structurally similar to isopropyl myristate, were rapidly degraded by mixed sewage sludge1,2,3. Low viscosity fluid nongreasy emollient, tolerates wide ph range, compatible with most surfactants. The high molar ratio of alcohol to acid creates novel. New york state integrated pest management, cornell university, geneva ny. Tetradecanoic acid, 1methylethyl ester chemical formula. A wide variety of isopropyl myristate options are available to you, there are 360 suppliers who sells isopropyl myristate on, mainly located in asia. Isopropyl myristate finds many applications in food, cosmetic and pharmaceutical industries as an emollient, thickening agent, or lubricant. Stoma care products represent a common and previously. The frequency and concentration of use data are provided in table 8. Role of isopropyl myristate, isopropyl alcohol and a.
The top countries of suppliers are brazil, china, and malaysia, from which the percentage of isopropyl myristate supply is. Composed of of isopropyl alcohol a propane derivative and myristic acid a naturallyoccurring fatty acid, isopropyl myristate is a popular cosmetic and pharmaceutical ingredient. With the cas registry number 110270, it is also named as tetradecanoic acid 1methylethyl ester. This is a valuable attribute, as isopropyl myristate can help other skin healing chemicals to penetrate more deeply. Isopropyl myristate is being studied as a skin enhancer. Ipm 100, ipmex, ipmr, ipm, isopropyl tetradecanoate, myristic acid isopropyl. The isopropyl myristate is an organic compound with the formula c 17 h 34 o 2. Hazards identification reacts with strong oxidizing agents 5. The iupac name of this chemical is propan2yl tetradecanoate. Isopropyl myristate is a synthetic oil used as an emollient, thickening agent, or lubricant in beauty products. Despite its popularity with manufacturers, some side effects have been reported. Identification of the substancemixture and of the companyundertaking 1. The new york state department of health doh has evaluated the risk of the proposed use of isopropyl myristate on human health.
Committee to evaluate drugs ced recommendations and reasons this document posted april 2010 isopropyl myristate product. Isopropyl myristate, present at 100 mgl, reached 94% of its chemical oxygen demand in 28 days using a municipal waste water inoculum in the closed bottle test4. It is widely used as a nontoxic alternative for the control of head lice, as an emollient, and a lubricant. Role of isopropyl myristate, isopropyl alcohol and a combination of both in hydrocortisone permeation across the human stratum corneum. Final report on the safety assessment of myristyl myristate. Isopropyl myristate is a synthetic oil widely used in the cos. Therefore, isopropyl myristate is used as a solubilizing, spreading, and penetrat. Isopropyl myristate 98% isopropyl tetradecanoate sigma. Isopropyl myristate, nf 110270 is145 spectrum chemical. Sigmaaldrich offers a number of isopropyl myristate products.
Introduction isopropyl myristate ipm, the isopropyl ester of tetradecanoic acid, is used in cosmetics as a substi tute for natural oils because it is absorbed easily into the skin and has excellent spreading properties 1. This work was carried out to optimize the esterification process, between myristic acid and isopropanol, used for the production of isopropyl myristate in a reaction integrated distillation column. Isopropyl myristate tetradecanoic acid, 1 methylethyl ester cas 110270. Steritest ez system sterility testing of products to be diluted in isopropyl myristate filtration is the pharmacopoeia method of choice for sterility testing. Viscous products, such as creams and ointments, can be difficult to filter and are normally diluted in a sterile solvent, such as isopropyl myristate ipm. It has been attacked by scaremongers either from ignorance or more likely from a cynical desire to sell inferior products at high prices. Any website that suggests this material is harmful should be ignored. Isopropyl myristate is found in several everyday beauty products and is generally considered safe for consumer use. Isopropyl myristate, with the chemical formula ch 3 ch 2 12 cooch ch 3 2, is an ester of myristic acid, an essential fatty acid derived from palm kernel oil and isopropyl alcohol. It is manufactured through the condensation of isopropyl alcohol and mystic acid. Isopropyl myristate is a polar emollient and is used in cosmetic and topical medicinal preparations where good absorption into the skin is desired.
Amended safety assessment of alkyl esters as used in. Myristic acid isopropyl ester isopropyl tetradecanoate 1. Using a homogeneous reaction phase, nonspecific lipase derived from candida antartica, marketed as novozym 435, was determined to be most suitable for the enzymatic synthesis of isopropyl myristate. Ipm is used to dissolve lanolin and other oils, and is commonly used as a degreasant or softener in sunscreens, face creams and lipsticks. Isopropyl myristate, isopropyl myristate supplier, isopropyl myristate distributor, cas 110270, isopropyl myristate manufacturer, isopropyl myristate wholesale skip to main content covid19 status. Keep containers tightly closed in a dry, cool and wellventilated place. Certificate of analysis representative sample certificate product name. Isopropyl myristate ipm is the ester of isopropyl alcohol and myristic acid. Isopropyl myristate is perfectly safe as a cosmetic ingredient and there are no issues with it as far as end users are concerned.
Isopropyl myristate by parchem is an emulsifier, humectant, emollient, binding and masking agent. Firstaid measures general advice if symptoms persist, call a physician. Not available data may vary slightly with different lots or batches expiration date. Isopropyl myristate supplier distributor cas 110270. It is generally safe, although some people with skin conditions may wish to avoid products containing.
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